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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Polypurine reverse-Hoogsteen hairpin ： ウィキペディア英語版 Polypurine reverse-Hoogsteen hairpin Polypurine reverse-Hoogsteen hairpins (PPRHs) are non-modified oligonucleotides formed by double-stranded DNA molecules containing two polypurine domains linked by a pentathymidine loop. The two domains are bound by intramolecular reverse-Hoogsteen bonds allowing the formation of a hairpin structure. == Properties == PPRHs can bind to polypyrimidine stretches in either single- or double stranded DNA by Watson and Crick bonds establishing triple-stranded DNA structures. The formation of PPRHs triplexes takes place at physiological pH. PPRHs provoke a strand displacement. of the homopurine sequence of the target dsDNA, opening the two strands of the DNA. There are two types of PPRHs: i) Template-PPRHs that bind to the template strand of DNA, inhibiting transcription; and ii) Coding-PPRHs that bind to the coding strand of the DNA altering splicing. Both types of PPRHs decrease gene expression. PPRHs present high stability in serum and cells and show lack of immunogenicity not activating the innate inflammatory response. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Polypurine reverse-Hoogsteen hairpin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.